Neoantigen-encoding personalized virus-2

{
  "id": "MLC-T-ONC-015480",
  "term": "Neoantigen-encoding personalized virus-2",
  "field": "Oncology and biomedicine",
  "definition": "A personalized cancer vaccine comprised of a not yet disclosed oncolytic virus encoding tumor-specific neoantigens that have been identified through genetic sequencing of a patient’s tumor cells, with potential immunostimulatory and antineoplastic activities. Upon administration, the neoantigen-encoding personalized virus-2 (PSV-2) infects cells and expresses the tumor-specific neoantigens (TSNAs). This stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the TSNAs, leading to tumor cell lysis.",
  "synonyms": [
    "PSV-2",
    "PSV2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/neoantigen-encoding-personalized-virus-2/"
}