personalized neoantigen plasmid DNA melanoma vaccine EVX-02

{
  "id": "MLC-T-ONC-015982",
  "term": "personalized neoantigen plasmid DNA melanoma vaccine EVX-02",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA melanoma vaccine composed of DNA plasmid encoding multiple, melanoma patient-specific neoepitopes, which are highly immunogenic tumor associated antigens (TAAs), with potential immunostimulatory and antineoplastic activities. Upon intramuscular (IM) administration of personalized neoantigen plasmid DNA melanoma vaccine EVX-02, the plasmid DNA is taken up by antigen-presenting cells (APCs) and the expressed neoepitopes induce cytotoxic T-lymphocyte (CTL)-mediated immune responses against melanoma cells expressing these specific TAAs.",
  "synonyms": [
    "DNA-based melanoma vaccine EVX-02",
    "personalized melanoma vaccine EVX-02",
    "plasmid DNA melanoma vaccine EVX-02"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-neoantigen-plasmid-dna-melanoma-vaccine-evx-02/"
}