personalized cancer neoantigen vaccine MVA-PEV

{
  "id": "MLC-T-ONC-015973",
  "term": "personalized cancer neoantigen vaccine MVA-PEV",
  "field": "Oncology and biomedicine",
  "definition": "A personalized neoantigen booster vaccine comprised of a modified Vaccinia Ankara (MVA) viral vector encoding numerous patient-specific tumor neoantigens, which are identified based on patient-specific tumor mutations obtained from the individual's tumor, with potential immunostimulatory and antineoplastic activities. The neoantigens are the same as the ones in the priming vaccine GAd-PEV. Following administration of the priming vaccine GAd-PEV, the administration of the booster vaccine, personalized cancer neoantigen vaccine MVA-PEV, may further enhance CD8+ and CD4+ neoantigen-specific T-cell responses against the patient’s tumor cells expressing the neoantigens.",
  "synonyms": [
    "MVA-PEV",
    "nous-PEV booster vaccine MVA-PEV",
    "personalized vaccine MVA-PEV",
    "modified vaccinia Ankara tumor- specific neoantigen boosting vaccine MVA-PEV",
    "booster vaccine MVA-PEV"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/personalized-cancer-neoantigen-vaccine-mva-pev/"
}