anti-MUC1 CAR-transduced autologous T lymphocytes

{
  "id": "MLC-T-ONC-010901",
  "term": "anti-MUC1 CAR-transduced autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous T lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) against the human tumor-associated epithelial antigen mucin 1 (MUC1), with potential immunomodulating and antineoplastic activities. Autologous PBLs from a patient with MUC1-positive cancer are transduced with a retroviral vector that encodes the CAR gene specific for MUC1. After expansion in culture and reintroduction into the patient, anti-MUC1 CAR-transduced autologous T lymphocytes target and induce selective toxicity in MUC1-expressing tumor cells. MUC-1 is a human, hypoglycosylated tumor-associated antigen (TAA) overexpressed by epithelial cancer cells.",
  "synonyms": [
    "anti-MUC1 autologous CAR T Cells",
    "anti-MUC1 CAR-transduced autologous T cells",
    "anti-mucin1 autologous CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-muc1-car-transduced-autologous-t-lymphocytes/"
}