anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes

{
  "id": "MLC-T-ONC-010265",
  "term": "anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells.",
  "synonyms": [
    "FMC63-28Z CAR-transduced allogeneic T lymphocytes",
    "MSGV1-FMC63-28Z anti-CD19 CAR-transduced allogeneic T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd19-car-fmc63-28z-retroviral-vector-transduced-allogeneic-t-lymphocytes/"
}