autologous UCD19 CAR T cells

{
  "id": "MLC-T-ONC-011810",
  "term": "autologous UCD19 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous peripheral blood lymphocytes (PBLs) that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous UCD19 CAR-T cells recognize and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19, a B-cell-specific cell surface antigen is overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "autologous UCD19-CAR T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-ucd19-car-t-cells/"
}