autologous universal CAR-expressing T lymphocytes UniCAR02-T

{
  "id": "MLC-T-ONC-011811",
  "term": "autologous universal CAR-expressing T lymphocytes UniCAR02-T",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that has been genetically engineered to express a fully humanized, universal, second generation chimeric antigen receptor (CAR) with a CD28/CD3zeta co-stimulatory domain, and a binding domain that can recognize a peptide motive of an antigen-specific targeting module (TM), with potential immunomodulating and antineoplastic activities. Upon administration, autologous universal CAR-expressing T lymphocytes UniCAR02-T remain inactivated. Upon administration of an antigen-specific TM, the binding domain of UniCAR02-T binds to the nuclear antigen motif of the TM, and UniCAR02-T is activated when the antigen-binding moiety of the TM binds to the specific antigen expressed on tumor cells. This induces selective toxicity in and causes lysis of tumor cells expressing the specific antigen.",
  "synonyms": [
    "UniCAR02-T cells",
    "UniCAR-T",
    "autologous universal CAR-T cells UniCAR02-T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-universal-car-expressing-t-lymphocytes-unicar02-t/"
}