CD123-specific targeting module TM123

{
  "id": "MLC-T-ONC-012362",
  "term": "CD123-specific targeting module TM123",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of soluble adapter molecules consisting of an antigen-binding moiety targeting CD123 linked to a peptide motif recognizable by UniCAR02-T, that may be used to activate UniCAR02-T. Upon administration of CD123-specific targeting module (TM) TM123, and upon co-administration of UniCAR02-T, the antigen-binding moiety of TM123 targets and binds to cancer cells expressing CD123, and the binding domain of UniCAR02-T binds to the nuclear antigen motif of TM123. This activates UniCAR02-T, and induces selective toxicity in and causes lysis of CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness.",
  "synonyms": [
    "CD123-specific TM TM123",
    "CD123 target module TM123",
    "recombinant antibody derivative TM123"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd123-specific-targeting-module-tm123/"
}