autologous anti-CD123 CAR TCR/4-1BB-expressing T lymphocytes

{
  "id": "MLC-T-ONC-011349",
  "term": "autologous anti-CD123 CAR TCR/4-1BB-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Autologous, genetically engineered T lymphocytes that have been electroporated with a messenger RNA (mRNA) encoding a chimeric antigen receptor (CAR) consisting of an anti-human interleukin-3 receptor alpha chain (IL3RA; CD123) single chain variable fragment (scFv) coupled to the co-stimulatory signaling domains of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCR) CD3 complex (CD3-zeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, the mRNA-electroporated autologous anti-CD123 CAR TCR/4-1BB expressing T lymphocytes attach to cancer cells expressing CD123. This induces selective toxicity in and causes lysis of CD123-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances T cell activation and signaling after recognition of CD123. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness.",
  "synonyms": [
    "autologous RNA CART123 cells",
    "anti-CD123 CAR mRNA-electroporated autologous T lymphocytes",
    "RNA Anti-CD123 CAR T Cells",
    "RNA CART123 cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd123-car-tcr-4-1bb-expressing-t-lymphocytes/"
}