autologous anti-CD123 CAR-T cells

{
  "id": "MLC-T-ONC-011350",
  "term": "autologous anti-CD123 CAR-T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD123 (interleukin-3 receptor alpha chain or IL3RA), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD123 CAR-T cells target and bind to CD123 expressed on the surface of tumor cells. This induces selective toxicity in CD123-expressing tumor cells. CD123, the alpha subunit of the IL-3 receptor, regulates the proliferation, survival and differentiation of hematopoietic cells. It is overexpressed on a variety of cancers, including myeloid leukemia, and the increased expression of CD123 on leukemic stem cells (LSCs) is associated with poor prognosis.",
  "synonyms": [
    "autologous anti-CD123 CAR T cells",
    "autologous anti-CD123 chimeric antigen receptor T cells",
    "CD123 CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd123-car-t-cells/"
}