allogeneic anti-CD123 CAR-NK cells JD123

{
  "id": "MLC-T-ONC-009799",
  "term": "allogeneic anti-CD123 CAR-NK cells JD123",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of off-the-shelf (OTS), allogeneic natural killer (NK) cells engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human interleukin-3 receptor alpha chain (IL3RA; cluster of differentiation 123; CD123), with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD123 CAR-NK cells JD123 recognize, bind to and induce selective cytotoxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with both increased leukemic cell proliferation and aggressiveness.",
  "synonyms": [
    "allogeneic CD123-targeted CAR NK cells JD123"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd123-car-nk-cells-jd123/"
}