Autologous anti-CD147 CAR T cells

{
  "id": "MLC-T-ONC-011351",
  "term": "Autologous anti-CD147 CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous activated T cells that have been engineered to express chimeric antigen receptors (CARs) specific for the tumor-associated antigen (TAA) CD147 (Basigin; EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential antineoplastic activity. Upon administration back into the patient, the anti-CD147 CAR T-cells target and induce selective cytotoxicity in CD147-expressing tumor cells. CD147, a cell-surface glycoprotein of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors and plays an important role in tumor cell proliferation, migration, progression, and metastasis.",
  "synonyms": [
    "autologous CD147-CAR-expressing T cells",
    "autologous CD147-CART cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd147-car-t-cells/"
}