licartin

{
  "id": "MLC-T-ONC-014772",
  "term": "licartin",
  "field": "Oncology and biomedicine",
  "definition": "An immunoradioconjugate containing metuximab, an antibody fragment targeting the hepatocellular cancer (HCC)-associated antigen HAb18G/CD147, that is conjugated to the radioisotope iodine I 131, with potential antineoplastic activity. Upon administration, the metuximab moiety of licartin targets and binds to HAb18G/CD147 on HCC cells; upon internalization, the radioisotope I 131 delivers a cytotoxic dose of gamma radiation, thereby causing selective destruction of HAb18G/CD147-expressing cells. HAb18G/CD147, a member of CD147 family, is overexpressed in HCC and fibroblasts and its expression is associated with cancer cell progression and increased adhesion, invasion and metastasis.",
  "synonyms": [
    "iodine I 131 metuximab",
    "iodine[131I] metuximab",
    "[131I] mAb HAb18G/CD147",
    "(131)I-labeled HAb18 F(ab')(2)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/licartin/"
}