Iodine I 131 IPA

{
  "id": "MLC-T-ONC-014526",
  "term": "Iodine I 131 IPA",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of the tumor-specific amino acid derivative 4-iodo-L-phenylalanine labeled with iodine I 131, a beta emitting radionuclide, with potential antineoplastic activity. Upon administration, iodine I 131 IPA actively crosses the blood-brain barrier and accumulates specifically in gliomas, via the amino acid transport system l-amino acid transporter 1 (LAT1) over-expressed in malignant glioma cells. where it delivers a cytotoxic dose of beta radiation. Cells that are exposed to radiation may also release potent toxins into the intracellular environment, leading to radiation-induced biological bystander effects (RIBBE) and killing cells not directly exposed to the radiation. Iodine I 131 IPA may also act synergistically with external irradiation due to its radiosensitizing property.",
  "synonyms": [
    "131I-IPA",
    "4-[131I]iodo-L-phenylalanine",
    "4-L-[131I]iodo-phenylalanine",
    "I-131 IPA",
    "iodine-131 IPA"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-131-ipa/"
}