iodine I 131 monoclonal antibody F16SIP

{
  "id": "MLC-T-ONC-014531",
  "term": "iodine I 131 monoclonal antibody F16SIP",
  "field": "Oncology and biomedicine",
  "definition": "A fully human monoclonal antibody (MoAb) against human A1 domain of tenascin-C, in small immunoprotein (SIP) format conjugated with iodine 131 with potential antineoplastic activity. Iodine I 131 MoAb F16SIP binds to tenascin-C on the vascular tissues and delivers cytotoxic radiation to the tumors, thereby minimizing systemic radiotoxicity. Tenascin-C is a glycoprotein of the extracellular matrix, and the large isoform of this matrix protein is expressed and restricted around vascular structures in the tumor stroma of a variety of different tumors.",
  "synonyms": [
    "I-131 monoclonal antibody F16SIP",
    "(131I) monoclonal antibody F16SIP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-131-monoclonal-antibody-f16sip/"
}