Iodine I 131 anti-fibronectin antibody fragment L19-SIP

{
  "id": "MLC-T-ONC-014521",
  "term": "Iodine I 131 anti-fibronectin antibody fragment L19-SIP",
  "field": "Oncology and biomedicine",
  "definition": "An iodine 131 radioimmunoconjugate of a small immunoprotein (SIP), derived from the variable region fragment of human monoclonal antibody L19, that is directed against the extra-domain B (ED-B) of fibronectin, with potential radioimmunotherapeutic activity. The SIP moiety of iodine I 131 anti-fibronectin antibody fragment L19-SIP binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. Upon internalization, the I 131 radionuclide may selectively detect or deliver cytotoxic radiation to fibronectin-expressing tumor cells. ED-B of fibronectin, a naturally occurring marker of tissue remodeling and angiogenesis, is expressed in the majority of aggressive solid human tumors, whereas it is not detectable in normal vessels and tissues.",
  "abbreviation": "I-131 L19-SIP",
  "synonyms": [
    "I-131 antibody L19-SIP"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-131-anti-fibronectin-antibody-fragment-l19-sip/"
}