Bifikafusp alfa

{
  "id": "MLC-T-ONC-012011",
  "term": "Bifikafusp alfa",
  "field": "Oncology and biomedicine",
  "definition": "An immunoconjugate consisting of the recombinant form of the cytokine interleukin-2 (IL-2) fused to a human single-chain Fv (scFv) antibody fragment directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. The L19 moiety of bifikafusp alfa binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the IL-2 moiety may locally activate natural killer (NK) cells and macrophages, and may induce T cell cytotoxic immune responses against ED-B fibronectin-expressing tumor cells. This may specifically decrease the proliferation of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis and tumor growth.",
  "abbreviation": "L19-IL2",
  "synonyms": [
    "L19-IL2 monoclonal antibody-cytokine fusion protein"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bifikafusp-alfa/"
}