nemvaleukin alfa

{
  "id": "MLC-T-ONC-015467",
  "term": "nemvaleukin alfa",
  "field": "Oncology and biomedicine",
  "definition": "A selective effector cell activator protein and agonist of the intermediate-affinity interleukin-2 (IL-2) receptor with potential immunostimulating and antineoplastic activity. Upon administration, nemvaleukin alfa binds to and signals through the intermediate-affinity IL-2 receptor complex; this may selectively stimulate and activate natural killer (NK) cells and memory CD8 T-cells, leading to tumor cell elimination, while circumventing the activation of immunosuppressive cells that may prevent the anti-tumor response. IL-2 is a cytokine signaling molecule that plays a critical role in the immune response.",
  "synonyms": [
    "Intermediate-affinity IL-2R Agonist ALKS 4230",
    "Intermediate-affinity Interleukin-2 Receptor Agonist ALKS 4230"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nemvaleukin-alfa/"
}