alpha clash anti-IL-2 antibody fusion protein LAT010

{
  "id": "MLC-T-ONC-009971",
  "term": "alpha clash anti-IL-2 antibody fusion protein LAT010",
  "field": "Oncology and biomedicine",
  "definition": "An antibody fusion protein and interleukin-2 (IL-2) immunocytokine, with potential antineoplastic activity. Upon administration of the alpha-clash anti-IL-2 antibody fusion protein LAT010, the IL-2 moiety targets and binds to the intermediate-affinity IL-2 receptor beta,gamma (IL-2Rbg), thereby selectivity activating CD8+ T cells and natural killer (NK) cells against tumor cells. The alpha-clash anti-IL-2 antibody moiety of LAT010 prevents LAT010 from activating the high-affinity IL2Ralpha,beta,gamma receptor complex which may prevent severe IL-2-mediated systemic toxic effects.",
  "synonyms": [
    "antibody fusion protein LAT010",
    "IL-2-based immunocytokine LAT010",
    "a-Clash IL-2 antibody fusion protein LAT010",
    "immunocytokine LAT010"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alpha-clash-anti-il-2-antibody-fusion-protein-lat010/"
}