immunocytokine NHS-IL2-LT

{
  "id": "MLC-T-ONC-014385",
  "term": "immunocytokine NHS-IL2-LT",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein consisting of a mouse-human chimeric antibody directed against DNA released by necrotic tumor cells fused to two molecules of a genetically modified human interleukin-2 (IL-2) with potential antineoplastic activity. Upon administration, the antibody moiety of immunocytokine NHS-IL2-LT binds to DNA released by necrotic tumor cells located primarily at the core of necrotic solid tumors, delivering the IL-2 moiety. In turn, the IL-2 moiety of this agent activates the immune system to mount a cytotoxic T-lymphocyte response against nearby tumor cells.",
  "abbreviation": "Ch.14.18-IL2",
  "synonyms": [
    "interleukin-2 fusion protein MSB0010445"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/immunocytokine-nhs-il2-lt/"
}