DI-Leu16-IL2 immunocytokine

{
  "id": "MLC-T-ONC-013055",
  "term": "DI-Leu16-IL2 immunocytokine",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant fusion protein consisting of de-immunized and humanized anti-CD20 monoclonal antibody Leu16 fused to human cytokine interleukin-2 (IL2) with potential antineoplastic activity. The antibody moiety of DI-Leu16-IL2 immunocytokine binds to tumor cells expressing the CD20 antigen, which may result in an antibody-dependent cell-mediated cytotoxicity (ADCC) towards CD20-expressing tumor cells; the localized IL2 moiety of this fusion protein may stimulate natural killer (NK) and T-lymphocyte mediated immune responses, enhancing the ADCC response. De-immunization involves the modification of potential helper T cell epitopes that bind to MHC class II molecules; humanization involves combining recombinant murine variable (V) regions with human immunoglobulin light and heavy chain constant regions. CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes, is overexpressed by various cancer cell types.",
  "abbreviation": "DI-Leu16-IL-2",
  "synonyms": [
    "de-immunized anti-CD20-IL-2 immunocytokine DI-Leu16-IL-2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/di-leu16-il2-immunocytokine/"
}