Tucotuzumab celmoleukin

{
  "id": "MLC-T-ONC-017365",
  "term": "Tucotuzumab celmoleukin",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. The humanized monoclonal antibody moiety of tucotuzumab celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of this fusion protein may stimulate a cytotoxic T-cell antitumor immune response.",
  "synonyms": [
    "huKS-IL2 fusion protein",
    "KSA-Interleukin-2 Fusion Protein"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tucotuzumab-celmoleukin/"
}