anti-EpCAM/anti-CD3 bispecific antibody M701

{
  "id": "MLC-T-ONC-010637",
  "term": "anti-EpCAM/anti-CD3 bispecific antibody M701",
  "field": "Oncology and biomedicine",
  "definition": "A human-mouse chimeric bispecific antibody directed against both CD3 and epithelial cell adhesion molecule (EpCAM), with potential immunomodulating and antineoplastic activities. Upon administration, anti-EpCAM/anti-CD3 bispecific antibody M701 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and EpCAM on EpCAM-expressing tumor cells. This activates and redirects CTLs to EpCAM-expressing tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells.",
  "synonyms": [
    "EpCAM x CD3 bispecific antibody M701"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-epcam-anti-cd3-bispecific-antibody-m701/"
}