EpCAM-specific CAR-expressing autologous T lymphocytes

{
  "id": "MLC-T-ONC-013381",
  "term": "EpCAM-specific CAR-expressing autologous T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the antigen epithelial cell adhesion molecule (EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration, the EpCAM-specific CAR-expressing autologous T lymphocytes specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. EpCAM, a cell surface protein, is expressed by a variety of tumor cells.",
  "synonyms": [
    "EpCAM-specific CAR autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/epcam-specific-car-expressing-autologous-t-lymphocytes/"
}