TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells

{
  "id": "MLC-T-ONC-017215",
  "term": "TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells",
  "field": "Oncology and biomedicine",
  "definition": "A mixed preparation of allogeneic T lymphocytes that have been genetically modified to express either a chimeric antigen receptor (CAR) specific for the antigen transmembrane 4 L six family member 1 (TM4SF1) (CART-TM4SF1) or a CAR specific for epithelial cell adhesion molecule (EpCAM) (CART-EpCAM), with potential immunostimulating and antineoplastic activities. Upon administration of the TM4SF1-CAR/EpCAM-CAR-expressing autologous T cells, the TM4SF1-CAR-expressing autologous T cells specifically recognize and bind to TM4SF1-expressing tumor cells and the EpCAM-CAR-expressing autologous T cells specifically recognize and bind to EpCAM-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 and EpCAM are expressed by a variety of tumor cells.",
  "synonyms": [
    "TM4SF1-CAR autologous T cells/EpCAM-CAR autologous T cells",
    "autologous CART-TM4SF1 cells/CART-EpCAM cells",
    "autologous TM4SF1-targeting CAR T cells and EpCAM-targeting CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tm4sf1-car-epcam-car-expressing-autologous-t-cells/"
}