autologous anti-TM4SF1 CAR-T cells

{
  "id": "MLC-T-ONC-011503",
  "term": "autologous anti-TM4SF1 CAR-T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) transmembrane 4 L six family member 1 (TM4SF1) and containing a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFRt HER1t), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-TM4SF1 CAR-T cells specifically recognize and bind to TM4SF1-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 plays a key role in the regulation of cell development, activation, growth and motility, and is overexpressed by a variety of tumor cells.",
  "synonyms": [
    "TM4SF1-CAR-expressing autologous T cells",
    "autologous TM4SF1-CAR T cells",
    "autologous TM4SF1-positive CAR T cells",
    "autologous TM4SF1-positive CAR-T cells",
    "anti-TM4SF1-CAR-expressing autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-tm4sf1-car-t-cells/"
}