autologous CAR-T cells B4T2-001

{
  "id": "MLC-T-ONC-011527",
  "term": "autologous CAR-T cells B4T2-001",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for an as of yet undisclosed tumor-associated antigen (TAA), with potential immunostimulating and antineoplastic activities. Upon administration, autologous CAR-T cells B4T2-001 target and bind to the TAA-expressing tumor cells. This results in a cytotoxic T-lymphocyte (CTL) response against the tumor cells, the release of cytotoxic molecules and the induction of tumor cell lysis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-car-t-cells-b4t2-001/"
}