anti-EpCAM/anti-CD3 bispecific antibody A-337

{
  "id": "MLC-T-ONC-010635",
  "term": "anti-EpCAM/anti-CD3 bispecific antibody A-337",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engager (TCE) and bispecific antibody composed of two fragments targeting the tumor-associated antigen (TAA) human epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326) and one targeting the T-cell surface glycoprotein CD3, with potential immunomodulating and antineoplastic activities. Upon administration, anti-EpCAM/anti-CD3 bispecific antibody A-337 targets and binds to EpCAM on EpCAM-expressing tumor cells and CD3 on cytotoxic T lymphocytes (CTLs). This activates and redirects CTLs to EpCAM-expressing tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells.",
  "synonyms": [
    "anti-EpCAM/anti-EpCAM/anti-CD3 bispecific antibody A-337",
    "EpCAM x EpCAM x CD3 bispecific antibody A-337",
    "Itab A-337",
    "recombinant anti-EpCAM-CD3 antibody A-337"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-epcam-anti-cd3-bispecific-antibody-a-337/"
}