Simlukafusp alfa

{
  "id": "MLC-T-ONC-016740",
  "term": "Simlukafusp alfa",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant fusion protein comprised of a human monoclonal antibody directed against fibroblast activation protein-alpha (FAP) linked to an engineered, variant form of interleukin-2 (IL-2v), with potential immunostimulating and antineoplastic activities. Upon administration of simlukafusp alfa, the monoclonal antibody moiety recognizes and binds to FAP, thereby concentrating IL-2 in FAP-expressing tumor tissue. Subsequently, the IL-2 moiety of this fusion protein may stimulate a local immune response and activate natural killer (NK) cells and cytotoxic T cells. FAP is a cell surface protein that is expressed on a wide variety of cancer cells. IL-2v cannot bind to IL-2 receptor-alpha (CD25, IL2Ra) and does not activate regulatory T cells (Tregs).",
  "synonyms": [
    "FAP-IL2v FP RO6874281",
    "anti-FAP/interleukin-2 fusion protein RO6874281",
    "FAP-IL2v RO6874281",
    "aFAP-IL2v RO6874281"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/simlukafusp-alfa/"
}