IL-2 recombinant fusion protein ALT-801

{
  "id": "MLC-T-ONC-014359",
  "term": "IL-2 recombinant fusion protein ALT-801",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/il-2-recombinant-fusion-protein-alt-801/"
}