recombinant attenuated Salmonella typhimurium expressing IL-2

{
  "id": "MLC-T-ONC-016389",
  "term": "recombinant attenuated Salmonella typhimurium expressing IL-2",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, genetically engineered Salmonella typhimurium strain expressing a truncated form of the human cytokine interleukin-2 (IL-2) gene, with antitumor activity. Upon administration of recombinant attenuated S. typhimurium expressing IL-2 (SalpIL2), this Salmonella strain may selectively accumulate and divide in a variety of tumor types, and express IL-2. In turn, IL-2 may induce natural killer (NK) cell proliferation thereby enhancing their activity. This may inhibit the growth of tumor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-attenuated-salmonella-typhimurium-expressing-il-2/"
}