IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine

{
  "id": "MLC-T-ONC-014363",
  "term": "IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of allogeneic neuroblastoma tumor cells have been genetically modified to secrete the human cytokine interleukin-2 (IL-2) and the human chemokine lymphotactin (Lptn) with potential immunostimulating and antineoplastic activities. Upon administration, IL-2 and Lptn are secreted by the IL-2/Lptn gene-modified allogeneic neuroblastoma tumor cell vaccine, potentially enhancing the cytotoxic T lymphocyte (CTL) response elicited by vaccine neuroblastoma tumor-associated antigens (TAAs) against host neuroblastoma tumor cells. Produced by activated progenitor T cells, Lptn belongs to the C chemokine subfamily and is a potent chemotactic factor for lymphocytes; IL-2 stimulates natural killer (NK) cells and may enhance a vaccine-elicited CTL immune response against tumor cells.",
  "synonyms": [
    "interleukin-2/lymphotactin gene-modified allogeneic neuroblastoma tumor cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/il-2-lptn-gene-modified-allogeneic-neuroblastoma-tumor-cell-vaccine/"
}