Salmonella enterica serovar typhi ZH9

{
  "id": "MLC-T-ONC-016625",
  "term": "Salmonella enterica serovar typhi ZH9",
  "field": "Oncology and biomedicine",
  "definition": "A formulation containing a live-attenuated strain of the bacterium Salmonella typhi, with potential immunomodulating and antineoplastic activities. Upon administration of Salmonella enterica serovar Typhi ZH9, the Salmonella in ZH9 may cause a Salmonella-induced systemic reprogramming of myeloid cells within the tumor microenvironment (TME). This enhances the recruitment of innate and adaptive immune cells, including the upregulation of co-stimulatory and major histocompatibility (MHC) molecules on dendritic cells (DCs), natural killer (NK) cells, CD4+ and CD8+ T cells, monocytes, and macrophages. This may alleviate immune suppression, restore immune fitness and tissue immunosurveillance and re-activate an anti-tumor immune response.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/salmonella-enterica-serovar-typhi-zh9/"
}