therapeutic bacterial strain CJRB-101

{
  "id": "MLC-T-ONC-017112",
  "term": "therapeutic bacterial strain CJRB-101",
  "field": "Oncology and biomedicine",
  "definition": "A live bacterial strain, with potential immunostimulating and antineoplastic activities. Upon administration of the therapeutic bacterial strain CJRB-101, the bacteria activates M1 macrophage and induces repolarization of M2 macrophages. This increases C-X-C motif chemokine 9 (CXCL9) and 10 (CXCL10)-expressing M1 macrophages and induces a shift from M2 to M1 macrophage dominance in the tumor microenvironment (TME). This stimulates the recruitment of other immune cells, increases the population of antigen-presenting specialized dendritic cells (DCs) and activates cytotoxic CD8+ T cells in the TME. This may enhance anti-tumor immune responses, specifically a cytotoxic T-lymphocyte (CTL)-mediated killing of tumor cells, and may eradicate tumor cells.",
  "synonyms": [
    "bacterial strain formulation CJRB-101",
    "live bacterial strain CJRB-101",
    "live biotherapeutic product CJRB-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/therapeutic-bacterial-strain-cjrb-101/"
}