autologous SIRPa-depleted activated macrophages SI-101

{
  "id": "MLC-T-ONC-011766",
  "term": "autologous SIRPa-depleted activated macrophages SI-101",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous macrophages that are ex vivo activated and depleted of signal-regulatory protein alpha (SIRP-alpha; SIRPa; CD172a), with potential immunostimulatory and antineoplastic activities. Upon reintroduction into the patient, autologous SIRPa-depleted activated macrophages SI-101 elicits an anti-tumor immune response via the phagocytosis of tumor cells. In addition, the autologous SIRPa-depleted activated macrophages SI-101 promotes a pro-inflammatory tumor microenvironment (TME) and activates a cancer neoantigen-specific cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response. The depletion of SIRPa, an inhibitory protein expressed on macrophages and dendritic cells (DCs), prevents SIRPa/CD47-mediated inhibition of macrophage activity.",
  "synonyms": [
    "autologous SIRPa-low macrophages SI-101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-sirpa-depleted-activated-macrophages-si-101/"
}