bacterial type III secretion-based agent T3P-Y058-739

{
  "id": "MLC-T-ONC-011864",
  "term": "bacterial type III secretion-based agent T3P-Y058-739",
  "field": "Oncology and biomedicine",
  "definition": "A therapeutic based on a genetically-modified, live attenuated strain of the bacterium Yersinia enterocolitica that is able to deliver a combination of as of yet undisclosed type I interferons (IFN) and toll-like receptor (TLR) protein payloads, with potential immunomodulating and antineoplastic activities. Upon administration, bacterial type III secretion (T3S)-based agent T3P-Y058-739 may selectively target tumor cells, colonize and deliver the protein payloads into tumor cells. This may activate type I IFN- and TLR-mediated signaling, thereby activating an immune response and killing tumor cells.",
  "synonyms": [
    "Yersinia enterocolitica T3S-based protein delivery agent T3P-Y058-739",
    "bacterial T3S-based agent T3P-Y058-739",
    "bacterial type III secretion-based protein delivery agent T3P-Y058-739",
    "Yersinia enterocolitica-based therapeutic T3P-Y058-739"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bacterial-type-iii-secretion-based-agent-t3p-y058-739/"
}