salmonella VNP20009

{
  "id": "MLC-T-ONC-016626",
  "term": "salmonella VNP20009",
  "field": "Oncology and biomedicine",
  "definition": "A genetically stable Salmonella typhimurium strain, attenuated by chromosomal deletion of the purI and msbB genes, with tumor-targeting activity. In rodent models, salmonella VNP20009 has been shown to selectively accumulate and grow in a variety of tumor types, inhibiting the growth of primary and metastatic tumors. This agent may be genetically engineered to contain transgenes that express therapeutic agents or cell surface tumor-associated antigen-specific antibodies, such as CEA-specific antibodies, which may improve its tumor targeting and therapeutic potential.",
  "synonyms": [
    "auxotrophic lipid A S. typhimurium mutant",
    "live, attenuated Salmonella typhimurium"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/salmonella-vnp20009/"
}