Survivin-expressing CVD908ssb-TXSVN vaccine

{
  "id": "MLC-T-ONC-016923",
  "term": "Survivin-expressing CVD908ssb-TXSVN vaccine",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable Salmonella-based survivin vaccine composed of a weakened form of a live strain of Salmonella bacteria (CVD908ssb strain) that has been genetically modified to produce the tumor-associated antigen (TAA) survivin, with potential immunopotentiating and antineoplastic activities. Upon administration of the CVD908ssb-TXSVN vaccine, the expressed survivin stimulates the immune response to elicit a cytotoxic T-lymphocyte (CTL)-mediated immune response against survivin-expressing cancer cells, resulting in a decrease in tumor cell proliferation and an induction of tumor cell death. Survivin, a member of the inhibitor of apoptosis (IAP) family expressed during embryonic development, is upregulated in a variety of human cancers while absent in most normal adult cells; its expression in tumors is associated with a more aggressive phenotype, decreased survival, and increased resistance to chemotherapy.",
  "synonyms": [
    "Salmonella-based survivin vaccine CVD908ssb-TXSVN"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/survivin-expressing-cvd908ssb-txsvn-vaccine/"
}