survivin-targeted vaccine OVM-200

{
  "id": "MLC-T-ONC-016925",
  "term": "survivin-targeted vaccine OVM-200",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of recombinant overlapping peptides (ROPs) derived from the anti-apoptosis protein survivin, with potential immunopotentiating and antineoplastic activities. Upon administration, survivin-targeted vaccine OVM-200 may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against survivin-expressing tumor cells, resulting in decreased tumor cell proliferation and tumor cell death. The survivin protein inhibits caspase activation and apoptosis; it is undetectable in normal adult tissues but is expressed by several human cancers including lung, colon, breast, pancreas, and prostate cancer as well as hematopoietic malignancies and skin cancers.",
  "synonyms": [
    "survivin-targeting cancer vaccine OVM-200",
    "survivin peptides vaccine OVM-200",
    "survivin recombinant overlapping peptides vaccine OVM-200",
    "survivin ROPs vaccine OVM-200"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/survivin-targeted-vaccine-ovm-200/"
}