onfekafusp alfa

{
  "id": "MLC-T-ONC-015670",
  "term": "onfekafusp alfa",
  "field": "Oncology and biomedicine",
  "definition": "An immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor alpha (TNFalpha) fused to a human single-chain variable fragment (scFv) directed against the extra-domain B (ED-B) of fibronectin (L19), with potential immunopotentiating and antineoplastic activities. Upon adinistration, the L19 moiety of onfekafusp alfa binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. In turn, the TNFalpha moiety may locally induce an immune response against ED-B fibronectin-expressing tumor cells and may specifically decrease the proliferation of ED-B-expressing tumor cells. ED-B is predominantly expressed during angiogenesis and tumor growth.",
  "synonyms": [
    "L19-TNF-alpha",
    "Recombinant Human Fusion Protein L19TNFalpha",
    "Fibromun"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/onfekafusp-alfa/"
}