ondansetron hydrochloride

{
  "id": "MLC-T-ONC-006081",
  "term": "ondansetron hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to prevent nausea and vomiting caused by chemotherapy and radiation therapy and nausea and vomiting after surgery. Ondansetron hydrochloride blocks the action of a chemical called serotonin, which binds to certain nerves and may trigger nausea and vomiting. Blocking serotonin may help lessen nausea and vomiting. Ondansetron hydrochloride is a type of antiemetic and a type of serotonin receptor antagonist. Also called Zofran.",
    "The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytryptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting."
  ],
  "synonyms": [
    "Zofran"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ondansetron-hydrochloride/"
}