Granisetron

{
  "id": "MLC-T-ONC-003658",
  "term": "Granisetron",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs in adults to prevent nausea and vomiting caused by chemotherapy. Granisetron blocks the action of a chemical called serotonin, which binds to certain nerves and may trigger nausea and vomiting. Blocking serotonin may help lessen nausea and vomiting. Granisetron is a type of antiemetic and a type of serotonin receptor antagonist. Also called Sancuso and Sustol.",
    "An indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting."
  ],
  "synonyms": [
    "Sancuso",
    "Sustol"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/granisetron/"
}