Palonosetron hydrochloride

{
  "id": "MLC-T-ONC-006271",
  "term": "Palonosetron hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used in adults and children aged 1 month and older to prevent nausea and vomiting caused by chemotherapy and nausea and vomiting after surgery. Palonosetron hydrochloride blocks the action of a chemical called serotonin, which binds to certain nerves and may trigger nausea and vomiting. Blocking serotonin may help lessen nausea and vomiting. Palonosetron hydrochloride is a type of antiemetic and a type of serotonin receptor antagonist. Also called Aloxi.",
    "The hydrochloride salt of palonosetron, a carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB)."
  ],
  "synonyms": [
    "Aloxi",
    "palonosetron HCl"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/palonosetron-hydrochloride/"
}