Nanrilkefusp alfa

{
  "id": "MLC-T-ONC-015433",
  "term": "Nanrilkefusp alfa",
  "field": "Oncology and biomedicine",
  "definition": "A human fusion protein consisting of the cytokine interleukin (IL)-15 and the high-affinity binding sushi+ domain of IL-15 receptor alpha (IL-15Ra), with potential antineoplastic activities. Upon administration, nanrilkefusp alfa activates and increases the levels of natural killer (NK) cells and memory CD8+ T cells. The memory T cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. Nanrilkefusp alfa is more potent than unmodified IL-15 and does not require endogenous IL-15Ra for its action.",
  "synonyms": [
    "IL-15/IL-15 receptor alpha sushi+ domain fusion protein SO-C101",
    "interleukin-15/interleukin-15 receptor alpha sushi+ domain fusion protein SO-C101",
    "interleukin-15/interleukin-15 receptor alpha sushi+ domain fusion protein SOT101"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nanrilkefusp-alfa/"
}