nogapendekin alfa inbakicept-pmln

{
  "id": "MLC-T-ONC-015533",
  "term": "nogapendekin alfa inbakicept-pmln",
  "field": "Oncology and biomedicine",
  "definition": "A mutated form of the cytokine interleukin (IL)-15 (IL-15N72D), with potential immunomodulating and antineoplastic activities. Upon administration, nogapendekin alfa binds to the IL-15 receptor on natural killer (NK) and CD8+ T lymphocytes, which activates and increases the levels of NK cells and memory T cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation.",
  "abbreviation": "IL-15N72D/IL-15Ra-Fc",
  "synonyms": [
    "nogapendekin alfa inbakicept",
    "superagonist interleukin-15:interleukin-15 receptor alphaSu/Fc fusion complex Alt-803",
    "IL-15N72D-IL-15RaSU/Fc",
    "inbakicept nogapendekin alfa fusion complex"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/nogapendekin-alfa-inbakicept-pmln/"
}