interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306

{
  "id": "MLC-T-ONC-014481",
  "term": "interleukin-15/interleukin-15 receptor alpha complex-Fc fusion protein XmAb24306",
  "field": "Oncology and biomedicine",
  "definition": "An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T cells. The memory T cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.",
  "synonyms": [
    "IL15/IL15Ra complex-Fc fusion protein XmAb24306",
    "IL15/IL15Ra-Fc fusion protein XmAb24306"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/interleukin-15-interleukin-15-receptor-alpha-complex-fc-fusion-protein-xmab24306/"
}