iodine I 125 anti-EGFR-425 monoclonal antibody

{
  "id": "MLC-T-ONC-014520",
  "term": "iodine I 125 anti-EGFR-425 monoclonal antibody",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.",
  "synonyms": [
    "iodine 125-labeled anti-epidermal growth factor receptor-425 monoclonal antibody",
    "iodine 125-labeled anti-EGFR-425 monoclonal antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-125-anti-egfr-425-monoclonal-antibody/"
}