iodine I 131 iopofosine

{
  "id": "MLC-T-ONC-014525",
  "term": "iodine I 131 iopofosine",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of iopofosine, a phospholipid ether analog, labeled with the radioactive isotope iodine I 131, with potential antineoplastic activity. Upon administration, iodine I 131 iopofosine selectively accumulates in and retains within tumor cells for a prolonged period of time due to the decreased activity of a phospholipase D (PLD) in tumor cells compared to normal cells, thereby delivering cytotoxic radiation specifically to tumor cells. PLD is an enzyme found in the cell membrane of normal cells that degrades phospholipids.",
  "abbreviation": "I-131-CLR1404",
  "synonyms": [
    "131I-NM-404",
    "CLR131",
    "I-131 PLE analogue CLR1404",
    "PDC CLR 131",
    "iopofosine I 131",
    "CLR-1404 I-131",
    "phospholipid ether-drug conjugate CLR 131",
    "131I-CLR1404",
    "NM-404 I-131",
    "CLR 1404 I-131"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/iodine-i-131-iopofosine/"
}