Anti-CD147 Monoclonal Antibody DS-1471

{
  "id": "MLC-T-ONC-010242",
  "term": "Anti-CD147 Monoclonal Antibody DS-1471",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the tumor-associated antigen (TAA) CD147 (Basigin; EMMPRIN; extracellular matrix metalloproteinase inducer; OX47; 5A11), with potential antineoplastic activity. Upon administration, anti-CD147 monoclonal antibody DS-1471 targets and binds to CD147, thereby inhibiting the binding of CD147 to its binding molecules and CD147 molecular chaperone functions. This inhibits CD147-mediated stabilization and recycling of various CD147-binding proteins, including CD44, integrins, and monocarboxylate transporter 1 (MCT1), and inhibits downstream signal transduction pathways mediated by these proteins. This may lead to cancer cell death. CD147, a cell-surface glycoprotein of the immunoglobulin G (IgG) superfamily, is overexpressed in certain human tumors and plays an important role in tumor cell proliferation, migration, progression, and metastasis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd147-monoclonal-antibody-ds-1471/"
}