anti-CD123 monoclonal antibody CSL360

{
  "id": "MLC-T-ONC-010216",
  "term": "anti-CD123 monoclonal antibody CSL360",
  "field": "Oncology and biomedicine",
  "definition": "A chimeric IgG1 monoclonal antibody against CD123 (Interleukin-3 receptor alpha chain) with potential antineoplastic activity. Derived from mouse monoclonal antibody 7G3, anti-CD123 monoclonal antibody CSL360 binds to and neutralizes CD123 which is upregulated on leukemic stem cells (LSC) in acute myeloid leukemia (AML). This may inhibit IL-3-dependent signalling and proliferation and may prevent the uncontrolled growth and differentiation of mutated LSC.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd123-monoclonal-antibody-csl360/"
}